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While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)

Folic acid handling by the human gut: Implications for food fortification and supplementation

Production Methods of Glutathione Microbial fermentation method Modern industrial production of glutathione primarily relies on microbial fermentation using engineered strains of yeast or bacteria that overexpress enzymes in the glutathione biosynthesis pathway